Breaking the Cooperation Among Various Molecules Within Cancer Cells via Defection of Glutathione for Provoking Immunotherapy
Under the driving of evolutionary dynamics, multiple antioxidant molecules were over-expressed in tumor site for protecting cancer cells from oxidative pressure. Utilizing “game theory” to defect antioxidant molecules might be an appealing anti-cancer strategy as it could disrupt the cooperation between different molecules within tumor cells. Herein, we prepared a BEM NPs, once they were exposed to over-expressed glutathione in tumor cells, they underwent a dramatic morphological change from nanodots to irregular aggregations with micron-size through Michael addition, which could mechanically disrupt endosomal and plasma membrane, inducing cell death and activating anti-tumor immunological response. Ultimately, the combination of BEM and anti-CTLA4 contributed to the versatile inhibition of different types of tumor. We believe “game theory” would provide more thinking for prospective tumor treatment.
Image courtesy of Wenyao Zhen